I have the same problem. According to the mod_wsgi docs, --https://code.google.com/p/modwsgi/wiki/ConfigurationDirectives#WSGIPythonHome So, unless everybody using mod_wsgi on Heliohost switches to python 3, we're stuck with python 2.4.3 (for Johnny) and 2.7.1 (for Stevie). This is a dealbreaker for me. Without this, heliohost is unusable to me.