We will update our wiki article on how to get started with Flask eventually, but just posting a quick example here so people can comment and ask questions on this thread.
Create a directory on your main domain called flasktest. If you were transferred from cPanel your main domain will be parked on the public_html directory. If you created a new account on Plesk your directory will be httpdocs.
Create an .htaccess file inside the flasktest directory with these contents: